Sceletium tortuosum was used by South African pastoralists and hunter-gatherers as amood-altering substance from prehistoric times. The earliest written records ofthe use of the plant date back to. The traditionally prepared dried Sceletium was often chewed as a quid, and the saliva swallowed, but it has also been made into tea's and tinctures. Sceletium used to be inhaled as a snuff, or smoked,usually with the addition of other herbs.
Sceletium elevates mood and decreases anxiety, stress and tension. It is used to treat depression and is excellent for rehabilitating drug addictions as it is not addictive itself. In intoxicating doses it can cause euphoria, initially with stimulation and later with sedation. 

Long-term use in the local context followed by abstinence has not been reported to result in a withdrawal state. The plant is not hallucinogenic, and no severe adverse effects have been documented.
Sceletium tortuosum was used in rural areas in very small doses as a treatment for colic in infants, added to a teaspoon of breast milk, and this use still survives in some local communities.

Sprays, Tablets and capsules of Sceletium are being used successfully by a number of psychiatrists,psychologists and doctors with excellent results for anxiety states and mild to moderate depression; and they can also be used by the lay public as supplements to elevate mood and for stress and tension. In addition to Sceletium common use for the stress and mental fatigue of modern industrial living, Sceletium has been used as a natural supplement in:

Low mood, including grey weather syndrome
Anxiety states, including social phobia
Irritability in menopause
Improvement in libido, when lack of libido is from anxiety or low mood 
Post-traumatic stress disorder, as part of a support program

In addition to these better-known clinical uses,there is some preliminary evidence that Sceletium may be of value as a supplement in drug addiction rehabilitation and alcohol rehabilitation support,as part of a formal program. Research directions for the future include evaluation of potential in cognitive enhancement, and the management of Parkinson's Disease and Alzheimer's Disease.